POS0015 PREVALENCE OF NEUROPATHIES IN RHEUMATIC AND MUSCULOSKELETAL DISEASES

Background: In rheumatic and musculoskeletal diseases (RMDs), peripheral neurons can be affected, which result in sensory symptoms like pain, burning, tingling, numbness motor muscle-atrophy or even paresis. More detailed knowledge about the prevalence cause of neuropathy (NP) RMD are urgently needed, especially as patients may develop different subtypes NP. Objectives: The aim this project was to assess individual types NP rheumatoid arthritis (RA), spondyloarthritis (SpA) systemic sclerosis (SSc) patients, elucidate clinical, neurophysiological neuropathologic features associated Methods: Baseline questionnaires neurological physical examination were used presence neuropathic pain autonomic dysfunction. Laboratory tests performed exclude other causes for Electrophysiological differentiate demyelinating from axonal large fiber (LF)NPs. Additionally, skin biopsies detect an involvement small fibres (SF). Results: A total 31 (median age 64 years (range 43-75)) included. majority female (90%). mean disease duration 10 (1-41 years). than 50% diagnosed with RA, 7 SpA 6 SSc. Of 48% (15/31) had clinical signs those, showed 14 2, 4 mixed types. combined LFNP SFNP present 35% (11/31) patients. only a detectable, two no detectable. Conclusion: detectable 94% (29/31) predominating. This high proportion suggests surprisingly coincidence both diseases. Table 1. Subtypes Number Axonal 14/31 (45%) Demyelinating 2/31 (6%) Mixed 4/31 (12%) Sensory 9/31 (26%) Sensorimotor 5/31 (10%) Motor 1/31 (3%) Disclosure Interests: None declared.